DOI: 10.17586/2226-1494-2017-17-4-593-598


A. S. Demin, D. V. Novoselskiy, . , B. B. Damdinov

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Article in Russian

For citation: Demin A.S., Novoselskiy D.V., Baloshin Yu.A., Damdinov B.B. Permittivity research of biological solutions in gigahertz frequency range. Scientific and Technical Journal of Information Technologies, Mechanics and Optics , 2017, vol. 17, no. 4, pp. 593–598 (in Russian). doi: 10.17586/2226-1494-2017-17-4-593-598


Subject of Research. Wepresentresults of permittivity research in gigahertz frequency range for saline and glucose solutions used in medical practice. Experiment results are substantiated theoretically on the basis of Debye-Cole model. Method. Researches have been carried out on blood plasma of healthy donor, water, normal saline and glucose solutions with different concentration from 3 to 12 mmol/l. Experiments have been performed by an active nearfield method based on measuring the impedance of a plane air-liquid boundary with open end of coaxial waveguide in the frequency range from 1 to 12 GHz. Measurement results have been processed with the use of vector analyzer computer system from Rohde & Schwarz. Transmittance spectra have been determined by means of IR-spectrometer from TENZOR-Bruker. Main Results. Simulation results have shown good agreement between the experimental results and the model, as well as the choice of the main parameters of the Debye-Cole model in the studied frequency range for all media. It has been shown that the range of 3-6 GHz can be considered as the main one in the development of diagnostic sensors for the non-invasive analysis of the glucose concentration in the human blood. Practical Relevance. Electrodynamic models of test fluid replacing human blood give the possibility to simulate the sensor basic characteristics for qualitative and quantitative estimation of glucose concentration in human blood and can be used to create an experimental sample of a non- invasive glucometer.

Keywords: complex dielectric permittivity, water, saline solutions, glucose, biological tissues, near field, numerical model

 1.     Hofmann M., Ficher G., Weigel R., Kissinger D. Microwave-based noninvasive concentration measurements for biomedical applications. IEEE Transactions on Microwave Theory and Techniques, 2013, vol. 61, no. 5, pp. 2195–2204. doi: 10.1109/TMTT.2013.2250516
2.     Gabriel S., Lau R.W., Gabriel C. The dielectric propererties of biological tissues: II. Measurements in the frequency range 10 Hz to 20 GHz. Physics in Medicine and Biology, 1996, vol. 41, no. 11, pp. 2251–2269. doi: 10.1088/0031-9155/41/11/002
3.     King R.W.P., Smith G.S. Antennas in Matter. Cambridge, 1981.
4.     Nicolson A.M., Ross G.F. Measurement of the intrinsic properties of materials by time-domain techniques. IEEE Transactions on Instrumentation and Measurement, 1970, vol. 19, no. 4, pp. 377–382. doi: 10.1109/TIM.1970.4313932
5.     Nikawa Y., Someya D. Non-invasive measurement of blood sugar level by millimeter waves. IEEE MTT-S International Microwave Symposium Digest, 2001, vol. 3, pp. 171–174. doi: 10.1109/MWSYM.2001.966865
6.     Cole K.S., Cole R.H. Dispersion and absorption in dielectrics: I. Alternating current characteristics. Journal of Chemical Physics, 1941, vol. 9, pp. 341–351.
7.     Cole K.S., Cole R.H. Dispersion and absorption in dielectrics: II. Direct current characteristics. Journal of Chemical Physics, 1942, vol. 10, pp. 98–105.
8.     Ellison W. Permittivity of pure water at standard atmospheric pressure, over the frequency range 0-25 THz and the temperature range 0–100 ˚C. Journal of Physical and Chemical Reference Data, 2007, vol. 36, no. 1, pp. 1–18. doi: 10.1063/1.2360986 
9.     Klein L., Swift C. An improved model for the dielectric constant of sea water at microwave frequencies. IEEE Transactions on Antennas and Propagation, 1977, vol. 25, no. 1, pp. 104–111. doi: 10.1109/JOE.1977.1145319
10.  Chernous'ko F.L., Banichuk N.V. Variational Problems of Mechanics and Control. Moscow, Nauka Publ., 1973, 236 p.
11.  Bishay S.T. Numerical methods of the Cole-Cole parameters. Egypt. J. Sol., 2000, vol. 23, no. 2, pp. 179–188.
12.  Andryieusky A., Kuznetsova S.M., ZhukovskyS.V., Kivshar Y.S., Lavrinenko A.V. Water: promising opportunities for tunable all-dielectric electromagnetic metamaterials. Scientific Reports, 2013, vol. 5. doi: 10.1038/srep13535
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