INVESTIGATION OF SORPTION CHARACTERISTICS OF POLYMERIC MINERAL-FILLED COMPOSITES FOR MEDICINE

Y. A. Ignatieva, M. V. Uspenskaya, O. V. Borisov, R. O. Olekhnovich, R. A. Evseev, K. N. Kasanov


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Abstract

 The polymer compositions on the base of acrylic derivatives and bentonite particles modified by silver ions with various share and dispersion are received and studied by radical polymerization in the water. Partially neutralized acrylic acid, acrylamide and methylene-bis-acrilamide and particles of bentonite with fraction 0 - 0,05 mass.% are chosen as initial substances. The influence of bentonite concentration on absorbing characteristics of polymer materials in the distilled water is shown. It is demonstrated that the increase of bentonite fraction up to 5 mass.% leads to the rise of degree of equilibrium swelling by 1,5 – 2 times in comparison with an unfilled polymer matrix. The acrylic nanocompositions with a mass fraction of bentonite equal to 0,01 mass.% possess the greatest kinetic characteristics. Kinetic dependences of new composite materials swelling in physiological solution from a filler dispersion part are investigated. It is shown that in high dispersion (with particle size less than 0,25 mm) a part of mineral–containing filler equal to 1 mass.% leads to significant increase in values of equilibrium swelling degree in comparison with an unfilled sample (by 1,5 times). The effect of polyelectrolyte suppression of polymer composition swelling in physiological solution is studied. It results in values reduction of equilibrium swelling degree in comparison with these values in the distilled water. Application prospects for the received compositions are shown at bandages creation for wounds treatment of various etiologies. Research results are recommended for usage in medical practice for optimization of wound process march.


Keywords:  cross-linked copolymers, acrylic polymers, hydro-gels, swelling, sorption, bentonite, silver

Acknowledgements. The work was partially financially supported by the Government of the Russian Federation (grant 074- U01).

References

1. Лукьянов Г.Н., Успенская М.В. Количественное описание нелинейной динамики пористой акриловой тонкой пленки // Научно-технический вестник информационных технологий, механики и оптики. 2012. № 2 (78). С. 84–87.

2. Будтова Т.В., Сулейменов И.Е., Френкель С.Я. Сильнонабухающие полимерные гидрогели – некоторые современные проблемы и перспективы // Журнал прикладной химии. 1997. Т. 70. № 4. С. 529–539.

3. Polotsky A.A., Plamper F.A., Borisov O.V. Collapse-to-swelling transitions in pH- and thermoresponsive microgels in aqueous dispersions: the thermodynamic theory // Macromolecules. 2013. V. 46. N 21. P. 8702– 8709.

4. Итин А.Л., Лукин С.Б., Успенская М.В., Соловьев В.С. Исследование оптических свойств акрилового гидрогеля для систем индикации загрязнений // Изв. вузов. Приборостроение. 2012. Т. 55. № 7. С. 85–90.

5. Sandu T., Sârbu A., Constantin F., Vulpe S., Iovu H. Acrylic hydrogels-based biocomposites: synthesis and characterization // Journal of Applied Polymer Science. 2013. V. 127. N 5. P. 4061–4071.

 6. Yang S., Park K., Rocca J.G. Semi-interpenetrating polymer network superporous hydrogels based on poly(3-sulfopropyl acrylate, potassium salt) and poly(vinyl alcohol): synthesis and characterization // Journal of Bioactive and Compatible Polymers. 2004. V. 19. N 2. P. 81–100.

7. Павлюченко В.Н., Иванчев С.С. Композиционные полимерные гидрогели // Высокомолекулярные соединения. 2009. Т. 51. № 7. C. 1075–1095.

8. Ahmad M.B., Shameli K., Darroudi M., Yunus W.M.Z., Abrahim N.A., Hamid A.A., Zargar M. Synthesis and antibacterial activity of silver/montmorillonite nanocomposites // Research Journal of Biological Sciences. 2009. V. 4. N 9. Р. 1032–1036.

9. Borisova O.V., Zaremski M.Y., Borisov O.V., Billon L. The well-defined bootstrap effect in the macroinitiator-mediated pseudoliving radical copolymerization of styrene and acrylic acid // Polymer Science – Series B. 2013. V. 55. N 11–12. P. 573–576.

10. Касанов К.Н., Попов В.А., Евсеев Р.А., Андреев В.А., Везенцев А.И., Пономарева Н.Ф., Игнатьева Ю.А., Успенская М.В., Хрипунов А.К. Модифицированный серебром монтмориллонит: получение, антимикробная активность и медицинское применение в биоактивных раневых покрытиях // Научные ведомости Белгородского государственного университета. Серия: Медицина. Фармация. 2013. Т. 23. № 18. С. 188–197.

11. Попов В.А., Игнатьева Ю.А., Успенская М.В., Касанов К.Н. Синтез сорбирующих полимеров меди- цинского назначения // Известия СПбГТИ(ТУ). 2014. № 23 (49). С. 23–25.

12. Fong J., Wood F. Nanocrystalline silver dressings in wound management: a review // International Journal of Nanomedicine. 2006. V. 1. N 4. Р. 441–449.

13. Касанов К.Н., Попов В.А., Евсеев Р.А., Игнатьева Ю.А., Успенская М.В. Биоактивное гидрогелевое раневое покрытие. Заявка № 2013149052, опубл. 06.11.2013.

14. Pillai J.J., Thulasidasan A.K.T., Anto R.J., Chithralekha D.N., Narayanan A., Kumar G.S.V. Folic acid conjugated cross-linked acrylic polymer (FA-CLAP) hydrogel for site specific delivery of hydrophobic drugs to cancer cells // Journal of Nanobiotechnology. 2014. V. 12. N 1. Art. 25.

15. Wright J.B., Lam K., Hansen D., Burrell R.E. Efficacy of topical silver against fungal burn wound pathogens // American Journal of Infection Control. 1999. V. 27. N 4. P. 344–350.

16. Baker C., Pradhan A., Pakstis L., Pochan D.J., Shah S.I. Synthesis and antibacterial properties of silver nanoparticles // Journal of Nanoscience and Nanotechnology. 2005. V. 5. N 2. P. 244–249.

17. Banerjee I., Mishra D., Das T., Maiti T.K. Wound pH-responsive sustained release of therapeutics from a poly(NIPAAm-co-AAc) hydrogel // Journal of Biomaterials Science, Polymer Edition. 2012. V. 23. N 1–4. Р. 111–132.

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