Nikiforov
Vladimir O.
D.Sc., Prof.
doi: 10.17586/2226-1494-2017-17-5-782-789
LED DEVICE FOR PHOTODYNAMIC THERAPY OF ONYCHOMYCOSIS
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For citation: Belikov A.V., Semyashkina Yu.V., Modin M.A., Zhubrev D.R. LED device for photodynamic therapy of onychomycosis. Scientific and Technical Journal of Information Technologies, Mechanics and Optics, 2017, vol. 17, no. 5, pp. 782–789 (in Russian). doi: 10.17586/2226-1494-2017-17-5-782-789
Abstract
Subject of Research.We discuss the photodynamic therapy of onychomycosis (nail fungal disease). The paper presents device description and main technical characteristics of the efficient LED device for photodynamic therapy of onychomycosis. The relevance of presented study is associated with the high incidence of onychomycosis, the need to increase efficiency, comfort and reduce its treatment period. Method. The efficient LED with a wavelength equal to 656±10nm compatible with absorption wavelength of photosensitizer (radachlorin) was selected. The optical model of single LED was created. The light intensity distribution generated by twenty eight LEDs on the surface located at different distances from the source (LED board) was calculated. Main Results. On the basis of optical optimization calculation of light intensity distribution, the main parameters (dimensions, angles, shape) of the mirror reflector for LED radiation delivery were determined. The assembly parts were manufactured and breadboard model of modular LED device for photodynamic therapy of onychomycosis was assembled and tested. Engineering test has shown that to achieve therapeutic dose required for photodynamic therapy of onychomycosis in the square bounded by the rectangle 16х6 = 96cm2 (maximum area occupied by human foot toes), 20±2minutes will be necessary that is quite comfortable for the doctor and the patient.Practical Relevance. Afterengineering and clinical testing and certification the proposedLEDdevice can be applied in the state and private health care facilities of the Russian Federation for the photodynamic therapy of onychomycosis and other cases.
Acknowledgements. The authors are grateful to LLC "Nela" (Saint Petersburg) for their financial support, to Professor Mark L. Gelfond (FSBI «Petrov Research Institute of Oncology», Saint Petersburg) for initial impulse, stimulating this project and to Alexei V. Skripnik, Peter A. Gnatyuk and Vitaly N. Prokofiev (Department of Laser Technologies and Systems, ITMO University, Saint Petersburg) for their assistance in the device assembling, configuring, and testing.
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