DOI: 10.17586/2226-1494-2018-18-3-377-383


METAFILM-BASED BIOSENSOR FOR DETERMINATION OF GLUCOSE CONCENTRATION IN HUMAN BLOOD

V. Y. Soboleva, S. I. Gusev, M. K. Khodzitskiy


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Article in Russian

For citation: Soboleva V.Yu., Gusev S.I., Khodzitsky M.K. Metafilm-based biosensor for determination of glucose concentration in human blood. Scientific and Technical Journal of Information Technologies, Mechanics and Optics, 2018, vol. 18, no. 3, pp. 377–383 (in Russian). doi: 10.17586/2226-1494-2018-18-3-377-383

Abstract

 Subject of Research. The paper presents the study of metafilm application possibility as a biosensor for blood glucose concentration estimation purposes. Method. The metafilm used in this research is a bandpass filter based on cross-shaped resonators for terahertz frequency range. Transmission spectrum of this filter is being affected by the changing optical properties of surrounding media (refractive index, permittivity and others). A change in glucose concentration leads to a change in blood optical properties, therefore, if a filter has a contact with blood, there is a shift of blood transmission spectrum observed. The shift is going to lower frequencies direction, and the shift value depends on glucose concentration. Three frequencies for more detailed study are chosen based on our previous research of blood permittivity dependence on glucose level correlation. All transmission spectra are obtained as the results of numerical experiments in COMSOL Multiphysics software. Main Results. The general algorithm is developed for selection of filter metafilm geometrical parameters based on cross-shaped resonators for given resonance frequency and Q-factor. This algorithm is used for calculation of three biosensor parameters with different spectral characteristics aimed at determination of the best properties of metafilm filter for biosensor purposes. The possibility of metafilm-based biosensor application was proved for determination of blood glucose concentration. Modelling showed that a filter with higher resonance frequency (0.5 THz) has a higher sensitivity (from 2.0 mmol/l to 0.5 mmol/l in the range of 3.0-9.0 mmol/l). Practical Relevance. This method will give the possibility to avoid puncturing during glucose concentration test, because the change in blood chemical composition may demonstrate the influence on skin refractive index. Moreover, biosensors of this type are highly sensitive to the changes in the material optical properties


Keywords: biosensor, bandpass filter, metafilm, cross-shaped resonators, THz frequency range, glucose

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